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PF-2771
CAS No.
PF-2771 ( PF2771;PF 2771 )
Catalog No. M17078 CAS No.
PF-2771 is a potent, selective CENP-E inhibitor with IC50 of 16.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePF-2771
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NoteResearch use only, not for human use.
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Brief DescriptionPF-2771 is a potent, selective CENP-E inhibitor with IC50 of 16.1 nM.
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DescriptionPF-2771 is a potent, selective CENP-E inhibitor with IC50 of 16.1 nM; does not inhibit the ATPase activities of highly related kinesins (Eg5/KSP, chromokinesin and MCAK, IC50> 1 uM); selectively inhibits proliferation of basal breast cancer cell lines; regresses tumor growth correlated with increased phospho-HH3-Ser10 levels in a breast cancer xenograft tumor model.
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SynonymsPF2771;PF 2771
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetKinesin
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RecptorKinesin
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight554.08
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Molecular FormulaC29H36ClN5O4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 32 mg/mL
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SMILES——
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Chemical Name(S)-N-(1-(4-(2-acetyl-1-methyl-1H-imidazol-4-yl)phenyl)-3-(2-(dimethylamino)acetamido)propan-2-yl)-3-chloro-4-isopropoxybenzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kung PP, et al. Mol Cancer Ther. 2014 Aug;13(8):2104-15.
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