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Difopein

CAS No. 396834-58-5

Difopein( —— )

Catalog No. M14366 CAS No. 396834-58-5

A specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Difopein
  • Note
    Research use only, not for human use.
  • Brief Description
    A specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity.
  • Description
    A specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity; blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S, induces apoptosis of human glioma cells through down-regulating Bcl-2, up-regulating Bax and activating caspase-9 and caspase-3, and suppresses tumor growth in mice; also enhances the ability of cisplatin to kill cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    14-3-3 Protein
  • Recptor
    14-3-3 Protein
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    396834-58-5
  • Formula Weight
    6387.17
  • Molecular Formula
    C273H424N76O89S6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)O)NC(=O)CNC(=O)C(C)NC(=O)C(C)NC(=O)CNC(=O)C1CCCN1C(=O)C(CC(C)C)NC(=O)C(CS)NC(=O)C(CCSC)NC(=O)C(CC(=O)N)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C4CCCN4C(=O)C(C(C)C)NC(=O)C(CS)NC(=O)C(CC5=CNC=N5)NC(=O)C6CCCN6C(=O)C(C)NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(C)NC(=O)C(C)NC(=O)CNC(=O)C7CCCN7C(=O)C(CC(C)C)NC(=O)C(CS)NC(=O)C(CCSC)NC(=O)C(CC(=O)N)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC8=CNC9=CC=CC=C98)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C1CCCN1C(=O)C(C(C)C)NC(=O)C(CS)NC(=O)C(CC1=CNC=N1)NC(=O)C1CCCN1C(=O)C(C)NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CO)N
  • Chemical Name
    SADGAPHCVPRDLSWLDLEANMCLPGAAGLDSADGAPHCVPRDLSWLDLEANMCLPGAAGLE

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Masters SC, et al. J Biol Chem. 2001 Nov 30;276(48):45193-200. 2. Lalle M, et al. J Biol Chem. 2006 Feb 24;281(8):5137-48. 3. Cao W, et al. Apoptosis. 2010 Feb;15(2):230-41. 4. Foote M, et al. Biol Psychiatry. 2015 Sep 15;78(6):386-95.
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