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RB-011
CAS No. 1425049-26-8
RB-011( RB011 | RB-11 | RB11 )
Catalog No. M11793 CAS No. 1425049-26-8
A small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameRB-011
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells.
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DescriptionA small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells; ahs ED50 of 3 uM for apoptosis induction in Jurkat cells, inhibits A549 lung cancer cell growth in vitro and in vivo; exhibits a rounded morphology similar to that of 14-3-3ζ KO dermal fibroblasts, increasing signal flux through the ROCK pathway, impairing the ECM remodeling, and accelerating wound healing.
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In Vitro——
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In Vivo——
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SynonymsRB011 | RB-11 | RB11
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PathwayOthers
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Target14-3-3 Protein
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Recptor14-3-3 Protein
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Research Area——
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Indication——
Chemical Information
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CAS Number1425049-26-8
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Formula Weight302.525
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Molecular FormulaC21H36N+
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name1-methyl-1-(4-octylphenethyl)pyrrolidin-1-ium
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Woodcock JM, et al. Oncotarget. 2015 Jun 10;6(16):14522-36.
2. Kular J, et al. Dev Cell. 2015 Dec 21;35(6):759-74.
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