
Fusicoccin-A
CAS No. 20108-30-9
Fusicoccin-A( Fusicoccin | FC-A )
Catalog No. M13137 CAS No. 20108-30-9
A small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.
Purity : >98% (HPLC)






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Biological Information
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Product NameFusicoccin-A
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NoteResearch use only, not for human use.
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Brief DescriptionA small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.
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DescriptionA small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1; induces GCN1 turnover and neurite outgrowth, stimulates axon growth in vitro and regeneration in vivo; stabilizes the interaction between 14-3-3 and CFTR by selectively interacting with a secondary binding motif of CFTR (pS753).
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In VitroFusicoccin (Fusicoccin A) stabilizes a complex between 14-3-3 and the stress response regulator GCN1, inducing GCN1 turnover and neurite outgrowth (EC50=29 mM).Fusicoccin A activates the plasma membrane H+-ATPase by stabilizing its binding to 14-3-3 proteins, which results in water loss and the wilting of infected plants. Fusicoccin A decreases the proliferation and migration of human GBM cell lines in vitro, including several cell lines that exhibit varying degrees of resistance to pro-apoptotic stimuli. The IC50 growth inhibitory concentration of fusicoccin A is 92 μM in the U373-MG cells and 83 μM in the Hs683 glioma cells.
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In Vivo——
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SynonymsFusicoccin | FC-A
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PathwayOthers
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Target14-3-3 Protein
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Recptor14-3-3 Protein
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Research Area——
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Indication——
Chemical Information
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CAS Number20108-30-9
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Formula Weight680.82
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Molecular FormulaC36H56O12
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1C2CCC(C2=CC3(C(CC(=C3C(C1O)OC4C(C(C(C(O4)COC(C)(C)C=C)O)OC(=O)C)O)C(C)COC(=O)C)O)C)COC
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Chemical Nameα-D-Glucopyranoside, (1S,4R,5R,6R,6aS,9S,10aR)-3-[(1S)-2-(acetyloxy)-1-methylethyl]-1,2,4,5,6,6a,7,8,9,10a-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10a-dimethyldicyclopenta[a,d]cycloocten-4-yl 6-O-(1,1-dimethyl-2-propenyl)-, 3-acetate (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kaplan A, et al. Neuron. 2017 Mar 8;93(5):1082-1093.e5.
2. Stevers LM, et al. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1152-61.
molnova catalog



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Fusicoccin-A
A small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.