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14-3-3 Protein
The 14-3-3 protein was initially described as an acidic, abundant brain protein, they are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name is derived from the combination of its fraction number on DEAE-cellulose chromatography and its migration position in the subsequent starch–gel electrophoresis. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of functionally diverse signaling proteins, including kinases,phosphatases, and transmembrane receptors.
References:
1.Fu H, et al. Annu Rev Pharmacol Toxicol. 2000;40:617-47.
References:
1.Fu H, et al. Annu Rev Pharmacol Toxicol. 2000;40:617-47.
Others
14-3-3 Protein
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Difopein
catalog no : M14366
cas no: 396834-58-5
A specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity.
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14-3-3 inhibitor BV2
catalog no : M13948
cas no: 302602-92-2
A novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation.
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Fusicoccin-A
catalog no : M13137
cas no: 20108-30-9
A small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.
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RB-011
catalog no : M11793
cas no: 1425049-26-8
A small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells.
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FOBISIN 101
catalog no : M11527
cas no: 1370281-06-3
FOBISIN 101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively.