Elastase
Elastases are unique among the proteases in that they are capable of hydrolyzing the scleroprotein elastin.Elastases are proteinases capable of solubilizing fibrous elastin. They may belong to the class of serine proteinases, cysteine proteinases and metalloproteinases. Mammalian elastases occur mainly in the pancreas and the phagocytes. The enzymes include pancreatic elastases 1 (Protease E) and 2, and neutrophil elastase. These three elastases also have esterase and amidase activity toward synthetic substrates such as succinyl-trialanine-p-nitroanilide. Although the three enzymes are similar to each other in enzyme activity, they are quite different in immunoactivity. Neutrophil elastase (NE) is one of the physiologic proteolytic enzymes (serine proteases) that are required for neutrophil function and are involved in the inflammatory response to tissue injury such as sepsis or arthritis. NE is a destructive elastase that attacks the extracellular matrix and modulates inflammation and tissue remodeling.
References
1.Hayakawa T,et al. Nihon Rinsho. 1995;53(5):1192–1197.
2.Bieth JG. J Soc Biol. 2001;195(2):173–179.
References
1.Hayakawa T,et al. Nihon Rinsho. 1995;53(5):1192–1197.
2.Bieth JG. J Soc Biol. 2001;195(2):173–179.
Metabolic Enzyme/Protease
11β-HSD(15)
15-PGDH(1)
ACC(10)
ACE(11)
AChE(29)
Adenylate Cyclase(12)
ALDH(14)
Aldose Reductase(5)
Aminopeptidase(17)
BACE(18)
Casein Kinase(41)
CAT(5)
Cathepsin(9)
CETP(10)
COMT(2)
CPG2(1)
CYPs(6)
Decarboxylase(3)
Dehydrogenase(87)
DGAT(4)
Dopamine beta-hydroxylase(2)
DPP(27)
Elastase(6)
FAAH(19)
Factor Xa(24)
Fatty Acid Synthase(16)
Ftase(2)
FXR(22)
Glucokinase(1)
GSNOR(2)
Guanylate Cyclase(9)
HMGCR(17)
IDH(7)
IDO(19)
IMPDH(2)
LDH(2)
LDL(5)
Lipase(13)
Lipid(9)
Lipoxygenase(0)
MAGL(3)
MAO(52)
MMP(53)
NAMPT(7)
Neprilysin(6)
NKCC(0)
Other Targets(9)
P450(87)
PAI-1(7)
Phosphatase(51)
Phospholipase(42)
PPAR(86)
Protein Phosphatase/PTP(6)
Renin(8)
Retinoid Receptor(23)
SCD(6)
Steroid Sulfatase (STS)(2)
Thioredoxin(1)
TPH(5)
Transferase(24)
Vitamin(39)
Xanthine Oxidase (XAO)(6)
Elastase
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AZD-9819
catalog no : M16832
cas no: 956907-23-6
AZD-9819 is an inhibitor of human neutrophil elastase for potential treatment of chronic obstructive pulmonary disease. -
Sivelestat sodium tetrahydrate
catalog no : M13142
cas no: 201677-61-4
A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM. -
DMP-777
catalog no : M12248
cas no: 157341-41-8
A potent, selective, and orally active human leukocyte elastase (HLE) inhibitor with IC50 of 23 nM. -
Sivelestat sodium
catalog no : M12093
cas no: 150374-95-1
A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM. -
Sivelestat
catalog no : M11143
cas no: 127373-66-4
A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM.