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15-PGDH

15-PGDH is considered to be the key catabolic enzyme which controls the biological activity of the prostaglandins, the enzyme catalyzes the reversible oxidation of the 15 hydroxyl group of prostaglandins to produce a 15-keto metabtlite with greatly reduced biological activity. Because of the importance of 15-PGDH in the metabolism of the prostaglandins,there has been considerable interest in the effects of pharmacological drugs on enzyme activity.

References:

1.Ensor CM, et al. J Lipid Mediat Cell Signal. 1995 Oct;12(2-3):313-9.

Metabolic Enzyme/Protease

11β-HSD(15) 15-PGDH(1) ACC(10) ACE(9) AChE(29) Adenylate Cyclase(10) ALDH(14) Aldose Reductase(5) Aminopeptidase(17) BACE(18) Casein Kinase(41) CAT(5) Cathepsin(8) CETP(10) COMT(2) CPG2(1) CYPs(6) Decarboxylase(3) Dehydrogenase(87) DGAT(4) Dopamine beta-hydroxylase(2) DPP(28) Elastase(6) FAAH(19) Factor Xa(22) Fatty Acid Synthase(16) Ftase(2) FXR(22) Glucokinase(1) GSNOR(2) Guanylate Cyclase(9) HMGCR(17) IDH(7) IDO(20) IMPDH(2) LDH(2) LDL(5) Lipase(13) Lipid(9) Lipoxygenase(0) MAGL(3) MAO(51) MMP(48) NAMPT(7) Neprilysin(6) NKCC(0) Other Targets(8) P450(87) PAI-1(7) Phosphatase(49) Phospholipase(42) PPAR(86) Protein Phosphatase/PTP(6) Renin(7) Retinoid Receptor(23) SCD(6) Steroid Sulfatase (STS)(2) Thioredoxin(1) TPH(5) Transferase(24) Vitamin(39) Xanthine Oxidase (XAO)(6)