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Ferroptosis
Ferroptosis is an iron- and ROS-dependent form of regulated cell death (RCD). Ferroptosis is distinct from other forms of RCD at morphological, biochemical, and genetic levels. It is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. It can be induced by experimental compounds (e.g., erastin, Ras-selective lethal small molecule, and buthionine sulfoximine) or clinical drugs (e.g., sulfasalazine, sorafenib, and artesunate) in cancer cells and certain normal cells. Several molecules (e.g., VDAC2/3, glutathione peroxidase (GPX4), heat shock protein beta-1 (HSPB1), nuclear factor E2-related factor 2 (NRF2), NADPH oxidase (NOX), p53, and SLC7A11) regulate ferroptosis by directly or indirectly targeting iron metabolism and lipid peroxidation. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes such as cancer cell death, tissue injury, and T-cell immunity.
References
1.Xie Y, et al. Cell Death Differ. 2016;23(3):369–379.
References
1.Xie Y, et al. Cell Death Differ. 2016;23(3):369–379.
Apoptosis
Ferroptosis
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FSEN1
catalog no : M37112
cas no: 862808-01-3
FSEN1 is a novel and highly effective non-competitive FSP1 inhibitor with an IC50 value of 313 nM.
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ROS-generating?agent?1
catalog no : M37110
cas no: 2369030-41-9
Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR.
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BCP-T.A
catalog no : M35673
cas no: 2786829-70-5
BCP-T.A is an ferroptosis inducer that acts by binding to GPX4.
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MMRi62
catalog no : M35377
cas no: 352693-80-2
MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53).
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FINO2
catalog no : M35322
cas no: 869298-31-7
FINO2 is a potent ferroptosis-inducing compound that inhibits GPX4 activity. It functions as a stable oxidant, effectively oxidizing ferrous iron and demonstrating stability across varying pH levels.