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DAPK
Death associated protein kinase 1 (DAPK) is a serine/threonine kinase involved in the regulation of multiple cellular processes such as apoptosis, autophagy, cell migration, membrane blebbing, etc. Autophosphorylation of DAPK at Ser308 inhibits its catalytic activity and dephosphorylation at this site is an important marker for DAPK activation. The mouse embryonic fibroblasts (MEFs) from DAPK-/- mice showed decreased apoptotic response to overexpression of oncogenes such as c-myc and E2F due to the insufficient activation of the p19ARF-p53 pathway. DAPK is pro-apoptotic in response to both TNF-a and shear stress alone. The dysfunction of DAPK or DAPK related signalling pathways have been linked with various diseases such as cancer, stroke, inflammation and atherosclerosis.
References
1.Huang Y,et al. Apoptosis. 2014 Feb;19(2):371-86.
References
1.Huang Y,et al. Apoptosis. 2014 Feb;19(2):371-86.
Apoptosis
DAPK
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DAPK-IN-2
catalog no : M36987
cas no: 304000-05-3
DAPK-IN-2 (WAY-380496) is a DAPK inhibitor. DAPK-IN-2 has potential anticancer activity, regulates autophagy and can be used to study cerebral infarction and ischemic diseases.
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TC-DAPK 6
catalog no : M33509
cas no: 315694-89-4
TC-DAPK 6 is an ATP-competitive inhibitor of Death-associated protein kinase (DAPK) with IC50s of 69 and 225 nM for DAPK1 and DAPK3.
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DRAK2-IN-16
catalog no : M16339
cas no: 871837-60-4
DRAK2-IN-116 is a potent, selective DRAK2 inhibitor with IC50 of 3 nM.
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HS148
catalog no : M12969
cas no: 1892595-16-2
HS148 (DAPK3 inhibitor HS148) is a selective DAPK3 inhibitor with Ki of 119 nM.
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HS94
catalog no : M12968
cas no: 1892594-93-2
HS94 (DAPK3 inhibitor HS94) is a selective DAPK3 inhibitor with Ki of 126 nM, >20-fold selectivity over Pim kinases.