dCBP-1
CAS No. 2484739-25-3
dCBP-1 ( —— )
Catalog No. M28637 CAS No. 2484739-25-3
dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 177 | Get Quote |
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10MG | 312 | Get Quote |
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25MG | 530 | Get Quote |
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50MG | 758 | Get Quote |
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100MG | 1044 | Get Quote |
|
200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NamedCBP-1
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NoteResearch use only, not for human use.
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Brief DescriptiondCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.
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DescriptiondCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.(In Vitro):Treatment of the human haploid cell line HAP1 for 6 h with dCBP-1 revealed almost complete loss of both CBP and p300 between 10 and 1,000 nM doses. A time course analysis with 250 nM dCBP-1 revealed almost complete degradation of p300/CBP within an hour of treatment. dCBP-1 was also able to induce near-complete p300/CBP degradation across other multiple myeloma cell lines tested, including MM1R, KMS-12-BM, and KMS34.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2484739-25-3
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Formula Weight1028.1
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Molecular FormulaC51H63F2N11O10
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Purity>98% (HPLC)
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Solubility——
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SMILESCNC(N(CC1)Cc2c1n(C(CC1)CCN1C(CCOCCOCCOCCOCCNc(cc1)cc(C(N3C(CCC(N4)=O)C4=O)=O)c1C3=O)=O)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1cn(C)nc1)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Borooah J, Leaback DH, Walker PG. Studies on glucosaminidase. 2. Substrates for N-acetyl-beta-glucosaminidase. Biochem J. 1961 Jan;78(1):106-10.
molnova catalog
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