dCBP-1( —— )

Catalog No. M28637 CAS No. 2484739-25-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

dCBP-1
Note

Research use only, not for human use.
Brief Description

dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.
Description

dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.(In Vitro):Treatment of the human haploid cell line HAP1 for 6 h with dCBP-1 revealed almost complete loss of both CBP and p300 between 10 and 1,000 nM doses. A time course analysis with 250 nM dCBP-1 revealed almost complete degradation of p300/CBP within an hour of treatment. dCBP-1 was also able to induce near-complete p300/CBP degradation across other multiple myeloma cell lines tested, including MM1R, KMS-12-BM, and KMS34.
In Vitro

Western Blot Analysis Cell Line:Multiple myeloma cell line MM1S Concentration:10 nM, 100 nM, 250 nM, 500 nM, 1000 nM Incubation Time:6 hours Result:Revealed rapid degradation with near-complete loss of p300/CBP after 2 hours.
In Vivo

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Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

——
Research Area

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Indication

——

CAS Number

2484739-25-3
Formula Weight

1028.11
Molecular Formula

C51H63F2N11O10
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (48.63 mM)
SMILES

CNC(N(CC1)Cc2c1n(C(CC1)CCN1C(CCOCCOCCOCCOCCNc(cc1)cc(C(N3C(CCC(N4)=O)C4=O)=O)c1C3=O)=O)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1cn(C)nc1)=O
Chemical Name

——

1.Borooah J, Leaback DH, Walker PG. Studies on glucosaminidase. 2. Substrates for N-acetyl-beta-glucosaminidase. Biochem J. 1961 Jan;78(1):106-10.

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