653-47 hydrochloride( —— )

Catalog No. M23394 CAS No. 1224567-46-7

653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	215	In Stock
5MG	187	In Stock
10MG	353	In Stock
25MG	598	In Stock
50MG	833	In Stock
100MG	1135	In Stock
200MG	Get Quote	In Stock
500MG	2279	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

653-47 hydrochloride
Note

Research use only, not for human use.
Brief Description

653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15.
Description

653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.
In Vitro

653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15.
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

CREB
Research Area

——
Indication

——

Chemical Information

CAS Number

1224567-46-7
Formula Weight

407.29
Molecular Formula

C20H20Cl2N2O3
Purity

>98% (HPLC)
Solubility

DMSO:250 mg/mL?(613.81 mM;?Need ultrasonic)
SMILES

O=C(NC1=CC=C(C=C1O)Cl)C2=C(C=C3C=CC=CC3=C2)OCCCN.Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.

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