ZL0454 ( ZL-0454;ZL 0454 )

Catalog No. M13568 CAS No. 2229042-77-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ZL0454
Note

Research use only, not for human use.
Brief Description

ZL0454 is a potent, highly selective small-molecule BRD4 inhibitor with IC50 of 49 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.
Description

ZL0454 is a potent, highly selective small-molecule BRD4 inhibitor with IC50 of 49 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively; displays selectivity over BRD2, BRD3, and BRDT( BRD2-BD1 and BRD2-BD2, IC50=772 and 1836 nM); disrupts the BRD4 complex with Pol II and histones, inhibits poly(I:C)-induced expression of innate immune genes IL6 and CIG5 in human small airway epithelial cells (hSAECs) (IC50=0.62 and 0.57 uM); blocks Poly(I:C)-induced inflammation and neutrophilia in vivo.
Synonyms

ZL-0454;ZL 0454
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

2229042-77-5
Formula Weight

374.46
Molecular Formula

C18H22N4O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=S(C1=CC=C(/N=N/C2=CC(C)=C(O)C=C2N)C=C1)(NC3CCCC3)=O
Chemical Name

(E)-4-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-N-cyclopentylbenzenesulfonamide

1. Tian B, et al. Cell Rep. 2018 Apr 24;23(4):1138-1151.

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