SGC-iMLLT ( —— )

Catalog No. M17063 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

SGC-iMLLT
Note

Research use only, not for human use.
Brief Description

SGC-iMLLT is the first small molecule chemical probe for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively.
Description

SGC-iMLLT is the first small molecule chemical probe for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively, IC50 of 0.26 uM (MLLT1); SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interaction; dsiplays excellent selectivity over other human YD proteins (YEATS2/4) and bromodomains.
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

--
Formula Weight

388.48
Molecular Formula

C22H24N6O
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC2=C(N(C)N=C2)C=C1)NC3=CC=C4NC(CN5[C@@H](C)CCC5)=NC4=C3
Chemical Name

(S)-1-methyl-N-(2-((2-methylpyrrolidin-1-yl)methyl)-1H-benzo[d]imidazol-5-yl)-1H-indazole-5-carboxamide

1. Moustakim M, et al. Angew Chem Int Ed Engl. 2018 Oct 5. doi: 10.1002/anie.201810617.

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