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PFI-3
CAS No. 1819363-80-8
PFI-3 ( PF-6687252;PF-06687252 )
Catalog No. M12801 CAS No. 1819363-80-8
PFI-3 is a potent and cell active BRG/PB1 bromodomains inhibitor with Kd of 54-97 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 64 | In Stock |
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| 10MG | 95 | In Stock |
|
| 25MG | 198 | In Stock |
|
| 50MG | 302 | In Stock |
|
| 100MG | 448 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePFI-3
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NoteResearch use only, not for human use.
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Brief DescriptionPFI-3 is a potent and cell active BRG/PB1 bromodomains inhibitor with Kd of 54-97 nM.
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DescriptionPFI-3 is a potent and cell active BRG/PB1 bromodomains inhibitor with Kd of 54-97 nM; shows high selectivity over other bromodomains; exposure of embryonic stem cells to PFI-3 led to deprivation of stemness and deregulated lineage specification; markedly enhances the differentiation of trophoblast stem cells; attenuates adipocyte differentiation and dramatically decreases lipid accumulation; a first in class chemical probe for Family VIII bromodomains.
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SynonymsPF-6687252;PF-06687252
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorPB1(5)bromodomains;SMARCA2;SMARCA4
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1819363-80-8
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Formula Weight321.38
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Molecular FormulaC19H19N3O2
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Purity>98% (HPLC)
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SolubilityDMSO: 32.1 mg/mL (100 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESOC1=C(C(/C=C/N2[C@H](C3)CN(C4=NC=CC=C4)[C@H]3C2)=O)C=CC=C1
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Chemical Name(E)-1-(2-hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fedorov O, et al. Sci Adv. 2015 Nov 13;1(10):e1500723.
2. Vangamudi B, et al. Cancer Res. 2015 Sep 15;75(18):3865-78.
3. Gerstenberger BS, et al. J Med Chem. 2016 May 26;59(10):4800-11.
2. Vangamudi B, et al. Cancer Res. 2015 Sep 15;75(18):3865-78.
3. Gerstenberger BS, et al. J Med Chem. 2016 May 26;59(10):4800-11.
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