TP-238 ( TP238 )

Catalog No. M17062 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

TP-238
Note

Research use only, not for human use.
Brief Description

TP-238 (TP238) is a CECR2/BPTF bromodomains chemical probe with IC50 of 30nM against CECR2 and 350nM against BPTF in an alphascreen assay.
Description

TP-238 (TP238) is a CECR2/BPTF bromodomains chemical probe with IC50 of 30nM against CECR2 and 350nM against BPTF in an alphascreen assay, KD of 10nM for CECR2 and 120nM for BPTF in ITC assays; TP-238 has been profiled against the panel of 338 kinases and showed no activity at 1 uM, the closest off-target bromodomain inhibition is BRD9 with IC50 of 1.4 uM.
Synonyms

TP238
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

--
Formula Weight

458.58
Molecular Formula

C22H30N6O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=S(C1=NC(C2=CC=C(OCCCN(C)C)C=C2)=CC(NCCCN3N=CC=C3)=N1)(C)=O
Chemical Name

N-(3-(1H-pyrazol-1-yl)propyl)-6-(4-(3-(dimethylamino)propoxy)phenyl)-2-(methylsulfonyl)pyrimidin-4-amine