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Home - Products - Proteasome/Ubiquitin - DUB - USP7-IN-8

USP7-IN-8

CAS No. 2009273-60-1

USP7-IN-8( GNE-6776 )

Catalog No. M23902 CAS No. 2009273-60-1

USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 has anticancer effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    USP7-IN-8
  • Note
    Research use only, not for human use.
  • Brief Description
    USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 has anticancer effects.
  • Description
    USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 has anticancer effects.
  • In Vitro
    USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4.
  • In Vivo
    ——
  • Synonyms
    GNE-6776
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    USP7
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2009273-60-1
  • Formula Weight
    348.4
  • Molecular Formula
    C20H20N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:80mg/ml(230.08mM; need ultrasonic)
  • SMILES
    CCc(c(-c(cc1)ccc1O)c(N)nc1)c1-c(cc1)cnc1C(NC)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Blake R , Lello P D , Drummond J , et al. USP7 INHIBITOR COMPOUNDS AND METHODS OF USE:, US20160272588[P]. 2016.
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