Cart
sales@molnova.com
XL177A
CAS No. 2417089-74-6
XL177A( —— )
Catalog No. M24114 CAS No. 2417089-74-6
XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 282 | In Stock |
|
| 5MG | 187 | In Stock |
|
| 10MG | 297 | In Stock |
|
| 25MG | 506 | In Stock |
|
| 50MG | 714 | In Stock |
|
| 100MG | 1004 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameXL177A
-
NoteResearch use only, not for human use.
-
Brief DescriptionXL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
-
DescriptionXL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
-
In VitroWestern Blot Analysis Cell Line:MCF7 cells Concentration:0.001, 0.01, 0.1, 1, 10 μM Incubation Time:18-24 hours Result:The p53 and p21 protein levels remained high, but MDM2 protein levels matched DMSO control.
-
In Vivo——
-
Synonyms——
-
PathwayProteasome/Ubiquitin
-
TargetDUB
-
RecptorUSP7
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2417089-74-6
-
Formula Weight861.47
-
Molecular FormulaC48H57ClN8O5
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 25 mg/mL (29.02 mM)
-
SMILESO=C(NC1=CC(N=CN2CC3(O)CCN(C([C@H](CC4=CC=CC=C4)CCCNC(C5=CC(N=C(CCCC6)C6=C7Cl)=C7C=C5)=O)=O)CC3)=C(C=C1)C2=O)CCN8CCN(C)CC8
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Nathan J Schauer, et al. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Sci Rep.2020 Mar 24;10(1):5324.
molnova catalog
related products
-
USP7-IN-4
(R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays.
-
HBX 41108
HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.
-
USP8-IN-22d
A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.85 uM.
