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Home - Products - Proteasome/Ubiquitin - DUB - SJB2-043

SJB2-043

CAS No. 63388-44-3

SJB2-043( —— )

Catalog No. M20973 CAS No. 63388-44-3

SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SJB2-043
  • Note
    Research use only, not for human use.
  • Brief Description
    SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).
  • Description
    SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).
  • In Vitro
    SJB2-043 causes a dose-dependent decrease in ubiquitin-specific protease 1 (USP1) levels and a concomitant degradation of inhibitor of DNA-binding-1 (ID1) protein in the K562 cells at a micromolar drug concentration. SJB2-043 also causes a decrease in the levels of other ID proteins, namely ID2 and ID3 in K562 cells. SJB2-043 causes a dose-dependent decrease in the number of viable K562 cells, with an EC50 of approximately 1.07 μM. Moreover, SJB2-043 induces apoptosis of K562 cells in a dose-dependent manner.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    USP1-UAF1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    63388-44-3
  • Formula Weight
    275.26
  • Molecular Formula
    C17H9NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:3.33 mg/mL (12.10 mM)
  • SMILES
    O=C1c2ccccc2C(=O)c2oc(-c3ccccc3)nc21
  • Chemical Name
    2-Phenyl-naphth[23-d]oxazole-49-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jussara Maria Goncalves et al. The Role of the Complex USP1/WDR48 in Differentiation and Proliferation Processes in Cancer Stem Cells.[J]. Current stem cell research & therapy 2017.
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