UNC3866 ( UNC 3866;UNC-3866 )

Catalog No. M12899 CAS No. 1872382-47-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

UNC3866
Note

Research use only, not for human use.
Brief Description

A potent, selective PRC1 chromodomains antagonist that binds to CBX4 and CBX7 with Kd of 100 nM.
Description

A potent, selective PRC1 chromodomains antagonist that binds to CBX4 and CBX7 with Kd of 100 nM; displays 6- to 18-fold selectivity versus other CBX (CBX2/6/8) and CDY chromodomains, highly selectivity versus >250 other taergets in a Kme reader panel; inhibits PC3 cell proliferation with EC50 of 340 nM.
Synonyms

UNC 3866;UNC-3866
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

CBX7-H3
Research Area

Cancer
Indication

——

CAS Number

1872382-47-2
Formula Weight

795.02
Molecular Formula

C43H66N6O8
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 27 mg/mL
SMILES

CC(C)(C)C1=CC=C(C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN(CC)CC)C(N[C@@H](CO)C(OC)=O)=O)=O)=O)=O)=O)C=C1
Chemical Name

L-Serine, N-[4-(1,1-dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-, methyl ester

1. Stuckey JI, et al. Nat Chem Biol. 2016 Mar;12(3):180-7.
2. Barnash KD, et al. ACS Chem Biol. 2016 Sep 16;11(9):2475-83.

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