Cart
sales@molnova.com
OTS186935
CAS No. 2093400-18-9
OTS186935 ( OTS-186935;OTS 186935 )
Catalog No. M13285 CAS No. 2093400-18-9
OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameOTS186935
-
NoteResearch use only, not for human use.
-
Brief DescriptionOTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM.
-
DescriptionOTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM; causes a significant growth inhibitory effect in mouse xenograft models using MDA-MB-231 breast cancer cells as well as A549 lung cancer cells, at 25 mg/kg once daily for 14 days yielded a TGI of 60.8%; attenuates the levels of H3K9me3 in A549 xenograft mouse model.
-
SynonymsOTS-186935;OTS 186935
-
PathwayChromatin/Epigenetic
-
TargetHMTase
-
RecptorHMTase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2093400-18-9
-
Formula Weight463.97
-
Molecular FormulaC25H26ClN5O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCOC1=CC(=C(C=C1C2=CN3C=CC(=CC3=N2)N4CCC(C4)NCC5=CC=NC=C5)Cl)OC
-
Chemical Name(S)-1-(2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl)-N-(pyridin-4-ylmethyl)pyrrolidin-3-amine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Vougiouklakis T, et al. Oncotarget. 2018 Aug 7;9(61):31820-31831.
molnova catalog
related products
-
GSK503
GSK503 is a potent, specific EZH2 methyltransferase inhibitor that inhibits the methyltransferase activity of WT and mutant EZH2 with similar potency (Ki app=3-27 nM).
-
EPZ004777
EPZ004777 is a potent, selectiveDOT1Linhibitor withIC50of 0.4 nM.
-
A-196
A potent, selective and substrate-competitive inhibitor of protein lysine methyltransferases (PKMTs) SUV420H1 and SUV420H2 with IC50 of 25 nM and 144 nM, respectively.
