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UNC0638
CAS No. 1255580-76-7
UNC0638 ( UNC 0638;UNC-0638 )
Catalog No. M11040 CAS No. 1255580-76-7
A potent, selective, substrate-competitive inhibitor of G9a (EHMT2) and GLP (EHMT1) with IC50 of <15 nM and 19 nM in SAHH-coupled assays, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 49 | In Stock |
|
| 10MG | 73 | In Stock |
|
| 25MG | 133 | In Stock |
|
| 50MG | 243 | In Stock |
|
| 100MG | 370 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUNC0638
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, substrate-competitive inhibitor of G9a (EHMT2) and GLP (EHMT1) with IC50 of <15 nM and 19 nM in SAHH-coupled assays, respectively.
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DescriptionA potent, selective, substrate-competitive inhibitor of G9a (EHMT2) and GLP (EHMT1) with IC50 of <15 nM and 19 nM in SAHH-coupled assays, respectively; very weak activity against JmjD2E and DNMT1; inactive against EZH2, SETD7, DOT1L and SETD8; reduces the clonogenicity of MCF7 cells and the abundance of H3K9me2.
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SynonymsUNC 0638;UNC-0638
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorG9a;GLP
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1255580-76-7
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Formula Weight509.73
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Molecular FormulaC30H47N5O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILESCOC1=CC2=C(NC3CCN(C(C)C)CC3)N=C(C4CCCCC4)N=C2C=C1OCCCN5CCCC5
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Chemical Name4-Quinazolinamine, 2-cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vedadi M, et al. Nat Chem Biol. 2011 Jul 10;7(8):566-74.
2. Yu H, et al. Cell Death Dis. 2013 Feb 21;4:e506.
3. Renneville A, et al. Blood. 2015 Oct 15;126(16):1930-9.
2. Yu H, et al. Cell Death Dis. 2013 Feb 21;4:e506.
3. Renneville A, et al. Blood. 2015 Oct 15;126(16):1930-9.
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