CM-272 ( CM272;CM 272 )

Catalog No. M12852 CAS No. 1846570-31-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CM-272
Note

Research use only, not for human use.
Brief Description

CM-272 (CM272)is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 8 nM and 382 nM for G9a and DNMT1, respectively.
Description

CM-272 (CM272)is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 8 nM and 382 nM for G9a and DNMT1, respectively; also inhibits DNMT3A/3B/GLP with IC50 of 85/1,200/2 nM, respectively; inhibits cell proliferation and promotes apoptosis in different haematological neoplasias (AML, ALL and DLBCL); significantly prolongs survival of AML, ALL and DLBCL xenogeneic models.
Synonyms

CM272;CM 272
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

Cancer
Indication

——

CAS Number

1846570-31-7
Formula Weight

478.64
Molecular Formula

C28H38N4O3
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CCN(CC4)C)OC)OCCCN5CCCC5
Chemical Name

6-methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine

1. San José-Enériz E, et al. Nat Commun. 2017 May 26;8:15424.
2.Bárcena-Varela M, et al. Hepatology. 2018 Jul 16. doi: 10.1002/hep.30168.

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