Cart
sales@molnova.com
Home - Products - Proteasome/Ubiquitin - E1 - UC-764864

UC-764864

CAS No. 278806-03-4

UC-764864( —— )

Catalog No. M37227 CAS No. 278806-03-4

UC-764864 is a selective UBE2N inhibitor that blocks E1-UBE2N thioester transfer, inhibits innate immune signaling and induces cytotoxic effects in MDS/AML cell lines and primary cells. In addition, UC-764864 reduces the ubiquitination status of UBE2N and can be used to study leukemia.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 163 Get Quote
5MG 250 Get Quote
10MG 455 Get Quote
25MG 726 Get Quote
50MG 994 Get Quote
100MG 1314 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    UC-764864
  • Note
    Research use only, not for human use.
  • Brief Description
    UC-764864 is a selective UBE2N inhibitor that blocks E1-UBE2N thioester transfer, inhibits innate immune signaling and induces cytotoxic effects in MDS/AML cell lines and primary cells. In addition, UC-764864 reduces the ubiquitination status of UBE2N and can be used to study leukemia.
  • Description
    UC-764864 is a UBE2N inhibitor. UC-764864 inhibits UBE2N enzymatic activity. UC-764864 has cytotoxic effects and inhibition of UBE2N-dependent signaling in leukemic cells. UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    E1
  • Recptor
    E1/E2/E3 Enzyme
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    278806-03-4
  • Formula Weight
    322.42
  • Molecular Formula
    C19H18N2OS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C=CSC1=NC=2C=C(C=CC2N1)C)C3=CC=C(C=C3)CC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Barreyro L, et al. Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia. Sci Transl Med. 2022 Mar 9;14(635):eabb7695.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • ML 792

    ML 792 is a potent, seletive SUMO-activating enzyme (SAE) inhibitor with IC50 of 3 nM and 11 nM for SAE/SUMO1 and SAE/SUMO2, respectively.

  • NEDD8 inhibitor M22

    NEDD8 inhibitor M22 is a novel, potent, selective reversible NEDD8 activating enzyme (NAE) inhibitor.

  • TAS4464 hydrochlorid...

    TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).

Sign In Join Free