Trifluridine ( NSC 75520; NSC 529182; TFT; Trifluridine )

Catalog No. M15687 CAS No. 70-00-8

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Trifluridine
Note

Research use only, not for human use.
Brief Description

Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase.
Description

Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA.
Synonyms

NSC 75520; NSC 529182; TFT; Trifluridine
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

DNA/RNA Synthesis; Thymidylate synthase
Research Area

Cancer
Indication

——

CAS Number

70-00-8
Formula Weight

296.20
Molecular Formula

C10H11F3N2O5
Purity

>98%(HPLC)
Solubility

Ethanol: 59 mg/mL (199.18 mM); Water: 59 mg/mL (199.18 mM); DMSO: 59 mg/mL (199.18 mM)
SMILES

O=C1NC(C(C(F)(F)F)=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2)=O
Chemical Name

1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione.

1.Shintani M, et al. Oncol Rep. 2010 May; 23(5):1345-50.

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