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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - 2-(Methylamino)-1H-purin-6(7H)-one

2-(Methylamino)-1H-purin-6(7H)-one

CAS No. 10030-78-1

2-(Methylamino)-1H-purin-6(7H)-one( N2-methylguanine )

Catalog No. M26576 CAS No. 10030-78-1

2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids and a modified nucleoside.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    2-(Methylamino)-1H-purin-6(7H)-one
  • Note
    Research use only, not for human use.
  • Brief Description
    2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids and a modified nucleoside.
  • Description
    2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids and a modified nucleoside.(In Vitro):2-(Methylamino)-1H-purin-6(7H)-one is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min. 2-(Methylamino)-1H-purin-6(7H)-one is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding.
  • In Vitro
    2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding. 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min.
  • In Vivo
    ——
  • Synonyms
    N2-methylguanine
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    CYP3A
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    10030-78-1
  • Formula Weight
    165.156
  • Molecular Formula
    C6H7N5O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 1 mg/mL (6.06 mM)
  • SMILES
    CNc1nc(=O)c2[nH]cnc2[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Method for increasing HDL cholesterol levels?using?heteroaromatic phenylmethanes. United States Patent 6103733
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