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Tirofiban

CAS No. 144494-65-5

Tirofiban ( L-700462;MK-383;MK-0383 )

Catalog No. M11884 CAS No. 144494-65-5

A potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 60 In Stock
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100MG 354 In Stock
500MG 843 In Stock
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Biological Information

  • Product Name
    Tirofiban
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM.
  • Description
    A potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM, inhibition of platelet aggregation; displays > 24,000-fold over human umbilical vein endothelial cell fibrinogen receptors; inhibits ex vivo platelet aggregation induced by ADP in anesthetized dogs.Thrombosis Approved
  • Synonyms
    L-700462;MK-383;MK-0383
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Integrin
  • Recptor
    GPIIb/IIIa
  • Research Area
    Cardiovascular Disease
  • Indication
    Thrombosis

Chemical Information

  • CAS Number
    144494-65-5
  • Formula Weight
    440.60
  • Molecular Formula
    C22H36N2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: < 1 mg/mL
  • SMILES
    O=C(O)[C@H](CC1=CC=C(OCCCCC2CCNCC2)C=C1)NS(=O)(CCCC)=O
  • Chemical Name
    L-Tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hartman GD, et al. J Med Chem. 1992 Nov 27;35(24):4640-2.
2. Lynch JJ Jr, et al. J Pharmacol Exp Ther. 1995 Jan;272(1):20-32.
3. Cook NS, et al. Thromb Haemost. 1993 Nov 15;70(5):838-47.
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