BIO1211

Research use only, not for human use.

BIO1211 (BIO-1211) is a potent, highly specific integrin α4β1 (VLA-4) inhibitor with Kd/IC50 of 20 pM/4 nM for the activated form of α4β1.

BIO1211 (BIO-1211) is a potent, highly specific integrin α4β1 (VLA-4) inhibitor with Kd/IC50 of 20 pM/4 nM for the activated form of α4β1; displays >200-fold selectivity over a range of other integrins (IC50 >100 uM for α1β1, α5β1 and α6β1), and reacts only with activated VLA4; inhibits ovalbumin-induced lung inflammation in vivo.

BIO-1211;BIO 1211

Cell Cycle/DNA Damage

Integrin

Integrin

——

——

187735-94-0

708.81

C36H48N6O9

>98% (HPLC)

——

O=C(O)[C@H]1N(C([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C=C2)=O)=O)=O)=O)CCC1

L-Proline, N-[[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]-L-leucyl-L-a-aspartyl-L-valyl- (9CI)

(-20℃)

With Ice Pack

≥ 2 years