TBC3486 ( TBC-3486;TBC 3486 )

Catalog No. M13721 CAS No. 247044-77-5

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Product Name

TBC3486
Note

Research use only, not for human use.
Brief Description

A potent, selective, non-peptidic integrin α4β1 (VLA-4) antagonist with IC50 of 9 nM.
Description

A potent, selective, non-peptidic integrin α4β1 (VLA-4) antagonist with IC50 of 9 nM, displays 200-fold selectivity over α4β7 (IC50=2.1 uM); mimics VCAM-1 binding, preferentially inhibits the high-affinity form of the integrin α4, blocks integrin-dependent T-cell co-activation in vitro as well as proves to be efficacious in vivo at low doses in animal models of allergic inflammation; dose-dependently inhibits adhesion of ALL cells, prolongs the survival of xenotolerant mice bearing human leukemia cells in vivo.Asthma Discontinued
Synonyms

TBC-3486;TBC 3486
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

Integrin
Research Area

Inflammation/Immunology
Indication

Asthma

CAS Number

247044-77-5
Formula Weight

557.68
Molecular Formula

C27H31N3O6S2
Purity

>98% (HPLC)
Solubility

——
SMILES

CCCCC(C(=O)N(CC1=CC=CS1)CC2=CC=CS2)NC(=O)NC(CC(=O)O)C3=CC4=C(C=C3)OCO4
Chemical Name

(S)-3-(benzo[d][1,3]dioxol-5-yl)-3-(3-((S)-1-(bis(thiophen-2-ylmethyl)amino)-1-oxohexan-2-yl)ureido)propanoic acid

1. Hsieh YT, et al. Leukemia. 2014 Oct;28(10):2101-4.
2. Vanderslice P, et al. Biochem Biophys Res Commun. 2010 Oct 1;400(4):619-24.

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