Terameprocol

CAS No. 24150-24-1

Terameprocol ( EM-1421; tetramethyl Nordihydroguaiaretic Acid )

Catalog No. M27456 CAS No. 24150-24-1

Terameprocol is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol showed the strongest anti-HIV activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 41 Get Quote
25MG 74 Get Quote
50MG 119 Get Quote
100MG 194 Get Quote
200MG Get Quote Get Quote
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Biological Information

  • Product Name
    Terameprocol
  • Note
    Research use only, not for human use.
  • Brief Description
    Terameprocol is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol showed the strongest anti-HIV activity.
  • Description
    Terameprocol is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol showed the strongest anti-HIV activity.(In Vitro):In Vero cells, Terameprocol inhibited Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter with IC50 values of 11 and 43.5 μM, respectively. The IC50 of Terameprocol varied between 11.7 and 4 μM in 10 passages of HSV-1 and 4 passages of HSV-2 . Terameprocol inhibited Sp1-dependent Cdc2 gene expression. In M4N-treated transformed C3 cells, Terameprocol induced growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity . Terameprocol treatment suppressed expression of the Sp1-dependent survivin gene. In transiently and stably survivin-transfected C3 cells, Terameprocol reduced caspase-3 activation by 50% and 75%, respectively . Terameprocol inhibited the growth of a number of tumor cell lines by inducing apoptosis in a non-schedule-dependent manner . Terameprocol inhibited the synthesis of DNA by melanoma cells and causes cell cycle arrest in G0/G1 and G2/M phases of the cell cycle .(In Vivo):Terameprocol effectively inhibited the growth of human tumors in nude mice . Terameprocol inhibited the growth of both murine and human melanomas and human colon cancer without apparent hepatic or renal toxicity . In nude (nu/nu) mice bearing xenografts of human tumor types (Hep 3B, LNCaP, HT-29, MCF7, and K-562), treatment with Terameprocol (i.v. or i.p.) down-regulated Cdc2 and survivin genes expression .
  • Synonyms
    EM-1421; tetramethyl Nordihydroguaiaretic Acid
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    IFNAR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    24150-24-1
  • Formula Weight
    358.5
  • Molecular Formula
    C22H30O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1ccc(CC(C)C(C)Cc2ccc(OC)c(OC)c2)cc1OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61.
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