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Zalcitabine
CAS No. 7481-89-2
Zalcitabine( ddC | Dideoxycytidin )
Catalog No. M15852 CAS No. 7481-89-2
A pyrimidine analog reverse transcriptase inhibitor (NRTI) for the treatment of HIV/AIDS.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
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| 25MG | 29 | In Stock |
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| 50MG | 40 | In Stock |
|
| 100MG | 57 | In Stock |
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| 200MG | 75 | In Stock |
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| 500MG | 120 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameZalcitabine
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NoteResearch use only, not for human use.
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Brief DescriptionA pyrimidine analog reverse transcriptase inhibitor (NRTI) for the treatment of HIV/AIDS.
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DescriptionA pyrimidine analog reverse transcriptase inhibitor (NRTI) for the treatment of HIV/AIDS; also incorporates into the viral DNA, hence terminating the chain elongation due to the missing hydroxyl group; highly oral activity.HIV Infection Approved(In Vitro):Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells.
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In VitroZalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells.
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In Vivo——
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SynonymsddC | Dideoxycytidin
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research AreaInfection
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IndicationHIV Infection
Chemical Information
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CAS Number7481-89-2
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Formula Weight211.2178
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Molecular FormulaC9H13N3O3
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Purity>98% (HPLC)
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SolubilityDMSO: 16.67 mg/mL
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SMILESO=C1N=C(N)C=CN1[C@@H]2O[C@H](CO)CC2
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Chemical NameCytidine, 2',3'-dideoxy-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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