Tazifylline
CAS No. 79712-55-3
Tazifylline ( —— )
Catalog No. M26008 CAS No. 79712-55-3
(±)-Tazifylline is a specific and long-acting antagonist of histamine H1 receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 447 | Get Quote |
|
10MG | 651 | Get Quote |
|
25MG | 1017 | Get Quote |
|
50MG | 1368 | Get Quote |
|
100MG | 1782 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTazifylline
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NoteResearch use only, not for human use.
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Brief Description(±)-Tazifylline is a specific and long-acting antagonist of histamine H1 receptor.
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Description(±)-Tazifylline is a specific and long-acting antagonist of histamine H1 receptor.(In Vitro):Tazifylline potently inhibits contractions evoked by stimulation of histamine H1-receptors in isolated guinea pig ilea and exhibits high affinity in radioligand binding studies.(In Vivo):In anesthetized guinea pigs, Tazifylline causes an inhibition in histamine-induced bronchoconstriction and protects conscious animals from the lethal effect of large doses of the amine. In conscious rats, Tazifylline reduces the inflammatory effects of intradermal histamine. In conscious dogs, Tazifylline(orally) causes inhibition in histamine-induced skin inflammation for long periods of time, and in anesthetized animals attenuated that portion of the histamine-evoked hypotension attributable to stimulation of H1 receptors. Large oral doses of Tazifylline do not reduce spontaneous locomotor activity in mice, nor do they produce overt symptoms of behavioral depression in conscious rats.
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Synonyms——
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorPDE3
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Research Area——
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Indication——
Chemical Information
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CAS Number79712-55-3
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Formula Weight472.6
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Molecular FormulaC23H32N6O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESCn1c2ncn(CC(O)CN3CCN(CCCSc4ccccc4)CC3)c2c(=O)n(C)c1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Mochizuki N, et al. Cardiovascular effects of NSP-804 and NSP-805, novel cardiotonic agents with vasodilator properties. J Cardiovasc Pharmacol. 1993 Jun;21(6):983-95.
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