Bicyclol ( Bicyclol; SY 801; SY-801; SY801 )

Catalog No. M17171 CAS No. 118159-48-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

Bicyclol
Note

Research use only, not for human use.
Brief Description

Bicyclol(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic viral hepatitis B and C, and also has a certain level of inhibiting HBV and HCV replication.
Description

Bicyclol, also known as SY 801, is a hepatoprotective agent. Bicyclol upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Bicyclol induces cell cycle arrest and autophagy in HepG2 human hepatocellular carcinoma cells through the PI3K/AKT and Ras/Raf/MEK/ERK pathways. Bicyclol attenuates tetracycline-induced fatty liver associated with inhibition of hepatic ER stress and apoptosis in mice. Bicyclol promotes toll-like 2 receptor recruiting inosine 5'-monophosphate dehydrogenase II to exert its anti-inflammatory effect.
Synonyms

Bicyclol; SY 801; SY-801; SY801
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

HBV
Research Area

Infection
Indication

——

CAS Number

118159-48-1
Formula Weight

390.34
Molecular Formula

C19H18O9
Purity

98%
Solubility

DMSO : ≥ 68 mg/mL. 174.21 mM
SMILES

COc1c2c(c(c(c1)CO)c1c3c(c(cc1C(=O)OC)OC)OCO3)OCO2
Chemical Name

5'-(hydroxymethyl)-7,7'-dimethoxy-[4,4'-bi-1,3-benzodioxole]-5-carboxylic acid, methyl ester

1.Walsh, S.W., Y. Wang, and A. Killian, AA-2414, J Pharmacol Exp Ther, 1999. 290(1): p. 220-6.

Calculator

molnova catalog