LML-134
CAS No. 1542135-76-1
LML-134 ( —— )
Catalog No. M21945 CAS No. 1542135-76-1
LML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 174 | Get Quote |
|
5MG | 258 | Get Quote |
|
10MG | 410 | Get Quote |
|
25MG | 678 | Get Quote |
|
50MG | 954 | Get Quote |
|
100MG | 1287 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameLML-134
-
NoteResearch use only, not for human use.
-
Brief DescriptionLML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM).
-
DescriptionLML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM).
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetHistamine Receptor
-
RecptorH3 receptor
-
Research AreaNervous system
-
IndicationCircadian Rhythm Disorders
Chemical Information
-
CAS Number1542135-76-1
-
Formula Weight375.47
-
Molecular FormulaC19H29N5O3
-
Purity>98% (HPLC)
-
SolubilityDMSO:7.5 mg/ml(19.97 mM; Need ultrasonic)
-
SMILESCn1nc(ccc1=O)N1CCC(CC1)OC(=O)N1CCN(CC1)C1CCC1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Troxler T, et al. The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders. ChemMedChem. 2019 Jul 3;14(13):1238-1247.
molnova catalog
related products
-
Pyrilamine maleate
A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally.
-
Tazifylline
(±)-Tazifylline is a specific and long-acting antagonist of histamine H1 receptor.
-
Pitolisant
A potent and selective antagonist of H3 receptor with Ki/EC50 of 0.16/1.5 nM; no effect on H1, H2, H4 receptors (IC50>10 uM).