LML-134 ( —— )

Catalog No. M21945 CAS No. 1542135-76-1

LML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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50MG	954	Get Quote
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Biological Information

Product Name

LML-134
Note

Research use only, not for human use.
Brief Description

LML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM).
Description

LML-134 is an inverse agonist of Histamine 3 receptor (H3R)(hH3R cAMP and hH3R bdg with Kis of 0.3 nM and 12 nM).
Synonyms

——
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

H3 receptor
Research Area

Nervous system
Indication

Circadian Rhythm Disorders

Chemical Information

CAS Number

1542135-76-1
Formula Weight

375.47
Molecular Formula

C19H29N5O3
Purity

>98% (HPLC)
Solubility

DMSO:7.5 mg/ml(19.97 mM; Need ultrasonic)
SMILES

Cn1nc(ccc1=O)N1CCC(CC1)OC(=O)N1CCN(CC1)C1CCC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Troxler T, et al. The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders. ChemMedChem. 2019 Jul 3;14(13):1238-1247.

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