MK-0731

Research use only, not for human use.

MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM.

MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM; dispalys >20,000-fold selectivity for KSP over a panel of eight related kinesins (CENP-E, MKLP-1, Kif3A, Kif1B, uKHC, nKHC, KIF14, and MCAK); induces a mitotic block with an IC50 of 19 nM in cells that are refractory to paclitaxel due to P-gp overexpression; induces dose-dependent mitotic arrest in tumors and inhibits tumor growth in mouse xenograft.Solid Tumors Discontinued.

Apoptosis Analysis Cell Line:A2780 cells Concentration:0.415-300 nM Incubation Time:48 h Result:Induced apoptosis with an EC50 of 2.7 nM.

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MK0731

Cytoskeleton/Cell Adhesion Molecules

Kinesin

Kinesin

Cancer

Solid Tumors

845256-65-7

459.513

C25H28F3N3O2

>98% (HPLC)

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O=C(N1[C@@](C2=CC=CC=C2)(CO)C=C(C3=CC(F)=CC=C3F)C1)N([C@@H]4[C@H](F)CN(C)CC4)C

(S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

(-20℃)

With Ice Pack

≥ 2 years