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TMP-195
CAS No. 1314891-22-9
TMP-195( TMP 195 | TMP195 )
Catalog No. M11271 CAS No. 1314891-22-9
A first-in-class, potent, selective class IIa HDACs (HDAC4, HDAC5, HDAC7 and HDAC9) inhibtior with IC50 of 60, 59, 26, and 15 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 60 | In Stock |
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| 5MG | 101 | In Stock |
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| 10MG | 170 | In Stock |
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| 25MG | 341 | In Stock |
|
| 50MG | 410 | In Stock |
|
| 100MG | 602 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTMP-195
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NoteResearch use only, not for human use.
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Brief DescriptionA first-in-class, potent, selective class IIa HDACs (HDAC4, HDAC5, HDAC7 and HDAC9) inhibtior with IC50 of 60, 59, 26, and 15 nM, respectively.
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DescriptionA first-in-class, potent, selective class IIa HDACs (HDAC4, HDAC5, HDAC7 and HDAC9) inhibtior with IC50 of 60, 59, 26, and 15 nM, respectively; shows no significant inhibition for others HDACs; alters the tumour microenvironment and reduces tumour burden and pulmonary metastases by modulating macrophage phenotypes in mice; induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumours.
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In Vitro——
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In Vivo——
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SynonymsTMP 195 | TMP195
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC4|HDAC5|HDAC7|HDAC9
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1314891-22-9
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Formula Weight456.42
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Molecular FormulaC23H19F3N4O3
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Purity>98% (HPLC)
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SolubilityDMSO: 82 mg/mL (179.7 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(NCC(C1=COC(C2=CC=CC=C2)=N1)(C)C)C3=CC=CC(C4=NOC(C(F)(F)F)=N4)=C3
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Chemical NameN-(2-methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lobera M, et al. Nat Chem Biol. 2013 May;9(5):319-25.
2. Guerriero JL, et al. Nature. 2017 Mar 16;543(7645):428-432.
3. Cassetta L, et al. Cell Res. 2017 Aug;27(8):963-964.
4. Groselj B, et al. Mol Cancer Ther. 2017 Aug 24. pii: molcanther.0011.2017.
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