Tubacin

Research use only, not for human use.

Tubacin is a potent, selective inhibitor of class II histone deacetylase 6 (HDAC6) with IC50 of 4 nM.

Tubacin is a potent, selective inhibitor of class II histone deacetylase 6 (HDAC6) with IC50 of 4 nM, displays> 300-fold selectivity against all other HDAC isoforms; induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures, iinhibits proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma; also suppresses proliferation and induces apoptosis of AML cells.

Tubacin

Cell Cycle/DNA Damage

HDAC

HDAC6

Infection

——

537049-40-4

721.86

C41H43N3O7S

>98% (HPLC)

10 mM in DMSO

O=C(NC1=CC=C([C@@H]2O[C@H](C3=CC=C(CO)C=C3)C[C@H](CSC4=NC(C5=CC=CC=C5)=C(C6=CC=CC=C6)O4)O2)C=C1)CCCCCCC(NO)=O

Octanediamide, N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-, rel-

(-20℃)

With Ice Pack

≥ 2 years