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Tubacin

CAS No. 537049-40-4

Tubacin ( Tubacin )

Catalog No. M14908 CAS No. 537049-40-4

Tubacin is a potent, selective inhibitor of class II histone deacetylase 6 (HDAC6) with IC50 of 4 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tubacin
  • Note
    Research use only, not for human use.
  • Brief Description
    Tubacin is a potent, selective inhibitor of class II histone deacetylase 6 (HDAC6) with IC50 of 4 nM.
  • Description
    Tubacin is a potent, selective inhibitor of class II histone deacetylase 6 (HDAC6) with IC50 of 4 nM, displays> 300-fold selectivity against all other HDAC isoforms; induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures, iinhibits proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma; also suppresses proliferation and induces apoptosis of AML cells.
  • Synonyms
    Tubacin
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC6
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    537049-40-4
  • Formula Weight
    721.86
  • Molecular Formula
    C41H43N3O7S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(NC1=CC=C([C@@H]2O[C@H](C3=CC=C(CO)C=C3)C[C@H](CSC4=NC(C5=CC=CC=C5)=C(C6=CC=CC=C6)O4)O2)C=C1)CCCCCCC(NO)=O
  • Chemical Name
    Octanediamide, N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-, rel-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Haggarty SJ, et al. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94.
2. Butler KV, et al. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.
3. Saji S, et al. Oncogene. 2005 Jun 30;24(28):4531-9.
4. Rao R, et al. Blood. 2008 Sep 1;112(5):1886-93.
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