Cart
sales@molnova.com
TG693
CAS No. 885272-55-9
TG693 ( TG-693;TG 693 )
Catalog No. M16408 CAS No. 885272-55-9
TG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameTG693
-
NoteResearch use only, not for human use.
-
Brief DescriptionTG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM.
-
DescriptionTG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM; also potently inhibits haspin activity and weakly inhibits DYRK kinases in a panel of 313 recombinant kinases; promotes the skipping of the endogenous mutated exon 31 in DMD patient-derived cells and increases the production of the functional exon 31-skipped dystrophin protein; inhibits the phosphorylation of CLK1 substrate serine/arginine-rich proteins and modulates pre-mRNA splicing in the skeletal muscle in mice.
-
SynonymsTG-693;TG 693
-
PathwayCell Cycle/DNA Damage
-
TargetCLK
-
RecptorCLK
-
Research AreaOther Indications
-
Indication——
Chemical Information
-
CAS Number885272-55-9
-
Formula Weight195.23
-
Molecular FormulaC12H9N3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC12=C(NN=C2)C=CC(C3=CC=NC=C3)=C1
-
Chemical Name5-(pyridin-4-yl)-1H-indazole
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Sako Y, et al. Sci Rep. 2017 May 30;7:46126.
molnova catalog
related products
-
CLK inhibitor T3
CLK inhibitor T3 (T3) is a highly potent, selective, and cell-based stable CDC-like kinase (CLK) inhibitor with 0.67, 15 and 110nM for CLK1,2 and 3, respectively.
-
Leucettine L41
A novel potent cdc2-like kinase (CLKs) and DYRKs inhibitor with IC50 of 40, 35 and 15 nM for DYRK1A, DYRK2 and CLK1, respectively.
-
Leucettamine B
Leucettamine B is a potent inhibitor of CLK1 (IC50=15 nM), Dyrk1A (IC50=40 nM), and Dyrk2 (IC50=35 nM) and a moderate inhibitor of CLK3 (IC50=4.5 uM).
