Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - CLK - TG693

TG693

CAS No. 885272-55-9

TG693( TG-693 | TG 693 )

Catalog No. M16408 CAS No. 885272-55-9

TG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    TG693
  • Note
    Research use only, not for human use.
  • Brief Description
    TG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM.
  • Description
    TG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM; also potently inhibits haspin activity and weakly inhibits DYRK kinases in a panel of 313 recombinant kinases; promotes the skipping of the endogenous mutated exon 31 in DMD patient-derived cells and increases the production of the functional exon 31-skipped dystrophin protein; inhibits the phosphorylation of CLK1 substrate serine/arginine-rich proteins and modulates pre-mRNA splicing in the skeletal muscle in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TG-693 | TG 693
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    CLK
  • Recptor
    CLK
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    885272-55-9
  • Formula Weight
    195.225
  • Molecular Formula
    C12H9N3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C12=C(NN=C2)C=CC(C3=CC=NC=C3)=C1
  • Chemical Name
    5-(pyridin-4-yl)-1H-indazole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sako Y, et al. Sci Rep. 2017 May 30;7:46126.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • KH-CB19

    KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1).

  • ML197

    ML197 is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.

  • CGP-74514A

    A potent, dual CDC-like kinase (CLK)/CDK inhibitor with IC50 of 148, 111, 104, 382 and 573 nM for CLK1, CLK2, CLK4, CDK1 and CDK4, respectively.

Sign In Join Free