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TG693
CAS No. 885272-55-9
TG693 ( TG-693;TG 693 )
Catalog No. M16408 CAS No. 885272-55-9
TG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameTG693
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NoteResearch use only, not for human use.
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Brief DescriptionTG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM.
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DescriptionTG693 is an orally available, selective, ATP-competitive CLK1 inhibitor with IC50 of 112.6 nM; also potently inhibits haspin activity and weakly inhibits DYRK kinases in a panel of 313 recombinant kinases; promotes the skipping of the endogenous mutated exon 31 in DMD patient-derived cells and increases the production of the functional exon 31-skipped dystrophin protein; inhibits the phosphorylation of CLK1 substrate serine/arginine-rich proteins and modulates pre-mRNA splicing in the skeletal muscle in mice.
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SynonymsTG-693;TG 693
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PathwayCell Cycle/DNA Damage
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TargetCLK
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RecptorCLK
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number885272-55-9
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Formula Weight195.23
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Molecular FormulaC12H9N3
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Purity>98% (HPLC)
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Solubility——
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SMILESC12=C(NN=C2)C=CC(C3=CC=NC=C3)=C1
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Chemical Name5-(pyridin-4-yl)-1H-indazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sako Y, et al. Sci Rep. 2017 May 30;7:46126.
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