KH-CB19 ( KH-CB-19 )

Catalog No. M11443 CAS No. 1354037-26-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

KH-CB19
Note

Research use only, not for human use.
Brief Description

KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1).
Description

KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1), displays almost 100-fold selectivity against the CLK3 isoform; effectively suppresses phosphorylation of SR (serine/arginine) proteins SRp75 and SRp55 in cells; significantly reduces the basal expression of flTF as well as asHTF, also lowers TNF-α-induced expression of both TF mRNA splice variants to baseline in HMEC-1 cells.
Synonyms

KH-CB-19
Pathway

Cell Cycle/DNA Damage
Target

CLK
Recptor

CLK
Research Area

Cancer
Indication

——

CAS Number

1354037-26-5
Formula Weight

338.19
Molecular Formula

C15H13Cl2N3O2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(C(N1C)=C(/C(C#N)=C\N)C2=C1C(Cl)=C(Cl)C=C2)OCC
Chemical Name

1H-Indole-2-carboxylic acid, 3-[(1E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-, ethyl ester

1. Fedorov O, et al. Chem Biol. 2011 Jan 28;18(1):67-76.

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