KH-CB19

CAS No. 1354037-26-5

KH-CB19( KH-CB-19 )

Catalog No. M11443 CAS No. 1354037-26-5

KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KH-CB19
  • Note
    Research use only, not for human use.
  • Brief Description
    KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1).
  • Description
    KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1), displays almost 100-fold selectivity against the CLK3 isoform; effectively suppresses phosphorylation of SR (serine/arginine) proteins SRp75 and SRp55 in cells; significantly reduces the basal expression of flTF as well as asHTF, also lowers TNF-α-induced expression of both TF mRNA splice variants to baseline in HMEC-1 cells.
  • In Vitro
    KH-CB19 (10 μM; 1 h) shows CLK inhibition on SR protein phosphorylation in human microvascular endothelial cells.KH-CB19 (50?μM; 6 h) inhibits the disruption by CLK4 in A549?cells. Western Blot Analysis Cell Line:Human microvascular endothelial cells (HMEC-1) Concentration:10 μM Incubation Time:1 hour Result:Led to a reduced phosphorylation of SRp75, SRp55, and SRp20 compared with non TNF-α-stimulated controls.Led to a reduction of the TNF-α-induced increase in phosphorylation of all analyzed SR proteins compared with TNF-α-stimulated controls.
  • In Vivo
    ——
  • Synonyms
    KH-CB-19
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    CLK
  • Recptor
    CLK
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1354037-26-5
  • Formula Weight
    338.1886
  • Molecular Formula
    C15H13Cl2N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C(N1C)=C(/C(C#N)=C\N)C2=C1C(Cl)=C(Cl)C=C2)OCC
  • Chemical Name
    1H-Indole-2-carboxylic acid, 3-[(1E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-, ethyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fedorov O, et al. Chem Biol. 2011 Jan 28;18(1):67-76.
molnova catalog
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