
KH-CB19
CAS No. 1354037-26-5
KH-CB19( KH-CB-19 )
Catalog No. M11443 CAS No. 1354037-26-5
KH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1).
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 340 | In Stock |
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50MG | 1269 | In Stock |
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100MG | 1791 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameKH-CB19
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NoteResearch use only, not for human use.
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Brief DescriptionKH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1).
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DescriptionKH-CB19 is a potent and highly specific inhibitor of CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4) with IC50 of 20 nM (CLK1), displays almost 100-fold selectivity against the CLK3 isoform; effectively suppresses phosphorylation of SR (serine/arginine) proteins SRp75 and SRp55 in cells; significantly reduces the basal expression of flTF as well as asHTF, also lowers TNF-α-induced expression of both TF mRNA splice variants to baseline in HMEC-1 cells.
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In VitroKH-CB19 (10 μM; 1 h) shows CLK inhibition on SR protein phosphorylation in human microvascular endothelial cells.KH-CB19 (50?μM; 6 h) inhibits the disruption by CLK4 in A549?cells. Western Blot Analysis Cell Line:Human microvascular endothelial cells (HMEC-1) Concentration:10 μM Incubation Time:1 hour Result:Led to a reduced phosphorylation of SRp75, SRp55, and SRp20 compared with non TNF-α-stimulated controls.Led to a reduction of the TNF-α-induced increase in phosphorylation of all analyzed SR proteins compared with TNF-α-stimulated controls.
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In Vivo——
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SynonymsKH-CB-19
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PathwayCell Cycle/DNA Damage
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TargetCLK
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RecptorCLK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1354037-26-5
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Formula Weight338.1886
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Molecular FormulaC15H13Cl2N3O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(C(N1C)=C(/C(C#N)=C\N)C2=C1C(Cl)=C(Cl)C=C2)OCC
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Chemical Name1H-Indole-2-carboxylic acid, 3-[(1E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-, ethyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fedorov O, et al. Chem Biol. 2011 Jan 28;18(1):67-76.
molnova catalog



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