ML197

CAS No. 1222891-88-4

ML197 ( NCGC00185963;ML 197 )

Catalog No. M10847 CAS No. 1222891-88-4

ML197 is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ML197
  • Note
    Research use only, not for human use.
  • Brief Description
    ML197 is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.
  • Description
    ML197 is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively; inhibits CLK2, CLK3 and Dyrk1B with IC50 of 1327, 7448 and 1510 nM, extends intracellular NKX3.1 half-life in LNCaP prostate cancer cells.
  • Synonyms
    NCGC00185963;ML 197
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    CLK
  • Recptor
    CLK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1222891-88-4
  • Formula Weight
    376.43
  • Molecular Formula
    C20H16N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    6-(benzo[d][1,3]dioxol-5-yl)-N-((2-methylthiazol-4-yl)methyl)quinazolin-4-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rosenthal AS, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3152-8.
2. Ewton DZ, et al. Mol Cancer Ther. 2011 Nov;10(11):2104-14.
3. Rosenthal AS, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
molnova catalog
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    ML197 is a potent, selective small molecule inhibitor of Cdc2-like kinases (CLK) and DYRK with IC50 of 96/40/206 nM for CLK1/CLK4/Dyrk1A, respectively.