T-00127-HEV1( T-00127-HEV1, T00127-HEV1, T 00127-HEV1, PI4KIIIβ Inhibitor II )

Catalog No. M16477 CAS No. 900874-91-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

T-00127-HEV1
Note

Research use only, not for human use.
Brief Description

T-00127-HEV1 is a broad-spectrum antienterovirus compound that selectively inhibits PI4KB activity with IC50 of 60 nM.
Description

T-00127-HEV1 is a broad-spectrum antienterovirus compound that selectively inhibits PI4KB activity with IC50 of 60 nM, inhibits poliovirus pseudovirus and EV71 in RD cells with IC50 of 0.77 and 0.73 uM; shows a moderate inhibitory effect on PIK3CD activity, and high selectivity over other PI kinases; demonstrates antipoliovirus activity ,does not inhibit hepatitis C virus (HCV) replication.
In Vitro

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In Vivo

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Synonyms

T-00127-HEV1, T00127-HEV1, T 00127-HEV1, PI4KIIIβ Inhibitor II
Pathway

Microbiology/Virology
Target

Enterovirus
Recptor

Enterovirus
Research Area

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Indication

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CAS Number

900874-91-1
Formula Weight

411.506
Molecular Formula

C22H29N5O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (121.51 mM)
SMILES

CC1=NC2=C(C3=CC=C(OC)C(OC)=C3)C(C)=NN2C(NCCN4CCOCC4)=C1
Chemical Name

3-(3,4-dimethoxyphenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine

1. Arita M, et al. J Virol. 2011 Mar;85(5):2364-72.

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