Seletalisib ( UCB-5857 )

Catalog No. M11495 CAS No. 1362850-20-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

Seletalisib
Note

Research use only, not for human use.
Brief Description

Seletalisib (UCB-5857)is a potent, ATP-competitive, and selective PI3Kδ inhibitor with IC50 of 12 nM.
Description

Seletalisib (UCB-5857)is a potent, ATP-competitive, and selective PI3Kδ inhibitor with IC50 of 12 nM; shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (204-303 fold); blocks AKT phosphorylation following activation of the B-cell receptor in a B-cell line; blocks human T-cell production of several cytokines from activated T-cells, and inhibits B-cell proliferation and cytokine release; dose-dependently inhibits anti-CD3-antibody-induced interleukin 2 release in mice.Psoriasis Phase 3 Clinical
Synonyms

UCB-5857
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

Inflammation/Immunology
Indication

Psoriasis

CAS Number

1362850-20-1
Formula Weight

482.85
Molecular Formula

C23H14ClF3N6O
Purity

>98% (HPLC)
Solubility

DMSO: ≥83.3 mg/mL
SMILES

FC(F)(F)[C@@H](C1=CC2=CC=CC(Cl)=C2N=C1C3=CC=C[N+]([O-])=C3)NC4=C5C(C=CC=N5)=NC=N4
Chemical Name

Pyrido[3,2-d]pyrimidin-4-amine, N-[(1R)-1-[8-chloro-2-(1-oxido-3-pyridinyl)-3-quinolinyl]-2,2,2-trifluoroethyl]-

1. Allen RA, et al. J Pharmacol Exp Ther. 2017 Jun;361(3):429-440.

Calculator

molnova catalog