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Home - Products - PI3K/Akt/mTOR signaling - PI3K - Duvelisib

Duvelisib

CAS No. 1201438-56-3

Duvelisib ( IPI-145;INK-1197 )

Catalog No. M10723 CAS No. 1201438-56-3

A potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 55 In Stock
10MG 77 In Stock
25MG 107 In Stock
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Biological Information

  • Product Name
    Duvelisib
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM.
  • Description
    A potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM; displays high selectivity for PI3K δ/γ than other protein kinases; exerts profound effects on adaptive and innate immunity by inhibiting B and T cell proliferation, blocking neutrophil migration, and inhibiting basophil activation; exhibits potent activity in collagen-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus rodent models.Blood Cancer Phase 3 Clinical
  • Synonyms
    IPI-145;INK-1197
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    1201438-56-3
  • Formula Weight
    416.86
  • Molecular Formula
    C22H17ClN6O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 41 mg/mL
  • SMILES
    O=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4N=CNC4=NC=N3)C)=CC5=C1C(Cl)=CC=C5
  • Chemical Name
    1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Winkler DG, et al. Chem Biol. 2013 Nov 21;20(11):1364-74.
2. Boyle DL, et al. J Pharmacol Exp Ther. 2014 Feb;348(2):271-80.
3. Dong S, et al. Blood. 2014 Dec 4;124(24):3583-6.
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