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Duvelisib
CAS No. 1201438-56-3
Duvelisib ( IPI-145;INK-1197 )
Catalog No. M10723 CAS No. 1201438-56-3
A potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 36 | In Stock |
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| 5MG | 55 | In Stock |
|
| 10MG | 77 | In Stock |
|
| 25MG | 107 | In Stock |
|
| 50MG | 142 | In Stock |
|
| 100MG | 230 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDuvelisib
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM.
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DescriptionA potent, selective PI3Kδ/γ inhibitor with Ki of 23 pM/243 pM, IC50 of 1 nM/50 nM; displays high selectivity for PI3K δ/γ than other protein kinases; exerts profound effects on adaptive and innate immunity by inhibiting B and T cell proliferation, blocking neutrophil migration, and inhibiting basophil activation; exhibits potent activity in collagen-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus rodent models.Blood Cancer Phase 3 Clinical
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SynonymsIPI-145;INK-1197
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1201438-56-3
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Formula Weight416.86
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Molecular FormulaC22H17ClN6O
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 41 mg/mL
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SMILESO=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4N=CNC4=NC=N3)C)=CC5=C1C(Cl)=CC=C5
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Chemical Name1(2H)-Isoquinolinone, 8-chloro-2-phenyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Winkler DG, et al. Chem Biol. 2013 Nov 21;20(11):1364-74.
2. Boyle DL, et al. J Pharmacol Exp Ther. 2014 Feb;348(2):271-80.
3. Dong S, et al. Blood. 2014 Dec 4;124(24):3583-6.
2. Boyle DL, et al. J Pharmacol Exp Ther. 2014 Feb;348(2):271-80.
3. Dong S, et al. Blood. 2014 Dec 4;124(24):3583-6.
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