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Home - Products - PI3K/Akt/mTOR signaling - PI3K - GSK-2292767

GSK-2292767

CAS No. 1254036-66-2

GSK-2292767 ( GSK2292767; GSK-2292767; GSK 2292767 )

Catalog No. M11026 CAS No. 1254036-66-2

GSK-2269557 is a highly potent and selective inhibitor of PI3Kδ (pKi=10.1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GSK-2292767
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK-2269557 is a highly potent and selective inhibitor of PI3Kδ (pKi=10.1).
  • Description
    GSK-2269557 is a highly potent and selective inhibitor of PI3Kδ (pKi=10.1); displays >1,000 fold selectivity versus others PI3K isoforms; inhibits both IFNγ and IL-2 production in a concentration-dependent manner, with pIC50 values of 8.7 and 8.5, respectively, in a human lung parenchyma assay; shows activity in rat acute OVA model of Th2-driven lung inflammation (ED50=35 ug/kg).COPD Phase 1 Clinical
  • Synonyms
    GSK2292767; GSK-2292767; GSK 2292767
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    PI3Kδ
  • Research Area
    Inflammation/Immunology
  • Indication
    COPD

Chemical Information

  • CAS Number
    1254036-66-2
  • Formula Weight
    512.58
  • Molecular Formula
    C24H28N6O5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CS(=O)(NC1=CC(C2=CC3=C(C(C4=NC=C(CN5C[C@@H](C)O[C@@H](C)C5)O4)=C2)C=NN3)=CN=C1OC)=O
  • Chemical Name
    N-(5-(4-(5-(((2R,6S)-2,6-dimethylmorpholino)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxypyridin-3-yl)methanesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Down K, et al. J Med Chem. 2015 Sep 24;58(18):7381-99.
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