NVP-BAG956 ( BAG 956 )

Catalog No. M16200 CAS No. 853910-02-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NVP-BAG956
Note

Research use only, not for human use.
Brief Description

NVP-BAG956 (BAG956) is a potent, dual PDK-1/PI3K inhibitor.
Description

NVP-BAG956 (BAG956) is a potent, dual PDK-1/PI3K inhibitor with IC50 of 245/56/446/35/117 nM for PDK1/p110α/p110β/p110δ/p110γ, respectively; inhibits p-T308-PKB U87MG cells with IC50 of 45 nM in ELISA assays, shows anti-proliferative activity with EC50 of 143 nM; blocks AKT phosphorylation induced by BCR-ABL–, and induces apoptosis of BCR-ABL–expressing cell lines and patient bone marrow cells at concentrations that also inhibit PI3K signaling; demonstrates against BCR-ABL expressing cells both in vitro and in vivo, BAG956 is effective against mutant FLT3-expressing cell lines and AML patient bone marrow cells.
Synonyms

BAG 956
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

Cancer
Indication

——

CAS Number

853910-02-8
Formula Weight

427.50
Molecular Formula

C28H21N5
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

c1cc(c(cc1CCCNCCCO)C(=O)NCC23CC4CC(C2)CC(C4)C3)Cl
Chemical Name

Benzeneacetonitrile, α,α-dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-

1. Stauffer F, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1027-30.

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