Scoulerine

CAS No. 6451-73-6

Scoulerine( (-)-Scoulerine | Discretamine )

Catalog No. M29229 CAS No. 6451-73-6

Scoulerine is an inhibitor of ?-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 286 Get Quote
5MG 482 Get Quote
10MG 687 Get Quote
25MG 1017 Get Quote
50MG 1395 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Scoulerine
  • Note
    Research use only, not for human use.
  • Brief Description
    Scoulerine is an inhibitor of ?-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
  • Description
    Scoulerine is an inhibitor of ?-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.(In Vitro):Scoulerine shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively. Scoulerine shows antiplasmodial activity with IC50 values of 5.4 μM and 3.1 μM against the antifolate sensitive and the multidrug resistant P. falciparum strains: TM4/8.2 and K1CB1, respectively.
  • In Vitro
    Scoulerine ((-)-Scoulerine) inhibits mini-panel of human leukemic cells, MOLT-4 (WT), Jurkat (TP53 mutated), Raji (TP53 mutated), HL-60 (TP53 null), U-937 (TP53 mutated), and HEL 92.1.7 (wild-type), with IC50s ranging from 2.7?μM to 6.5?μM.Scoulerine (2.5-20?μM; 24 hours) decreases proliferation of Jurkat and MOLT-4 cells.Scoulerine (2.5-20?μM; 24 hours) induces MOLT-4 and Jurkat cells apoptosis.Scoulerine induces G2 or M cell cycle arrest.Scoulerine (2.5-5?μM; 24?hours) shows an upregulation of p53 protein in p53 wild-type MOLT-4 cells.Scoulerine (2.5-5?μM; 24-48 hours) activates caspase-3/7, -8 and -9 in a dose-dependent manner.Scoulerine (5-10 μM; 24 hours) disrupts microtubule structure of A549 lung carcinoma cells .Cell Proliferation Assay Cell Line:Jurkat and MOLT-4 cellsConcentration:2.5, 5, 10, 15 and 20?μM Incubation Time:24?hours Result:Significantly reduced the viability and proliferation of Jurkat and MOLT-4 cells in a dose dependent manner.Apoptosis Analysis Cell Line:MOLT-4 and Jurkat cells Concentration:2.5, 5, 10, 15 and 20?μM Incubation Time:24 hours Result:Induced MOLT-4 and Jurkat cells apoptosis.Cell Cycle Analysis Cell Line:Jurkat and MOLT-4 leukemic cells Concentration:2.5-20 μM Incubation Time:16 hours Result:Induced cell cycle arrest at the G2/M transition.Western Blot Analysis Cell Line:MOLT-4 cells Concentration:2.5, 5?μM Incubation Time:24?hours Result:Showed an upregulation of p53 protein in p53 wild-type MOLT-4 cells.
  • In Vivo
    ——
  • Synonyms
    (-)-Scoulerine | Discretamine
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6451-73-6
  • Formula Weight
    327.38
  • Molecular Formula
    C19H21NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (305.46 mM)
  • SMILES
    COc1cc2CCN3Cc4c(C[C@H]3c2cc1O)ccc(OC)c4O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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