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Scoulerine

CAS No. 6451-73-6

Scoulerine ( (-)-Scoulerine; Discretamine )

Catalog No. M29229 CAS No. 6451-73-6

Scoulerine is an inhibitor of ?-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 286 Get Quote
5MG 482 Get Quote
10MG 687 Get Quote
25MG 1017 Get Quote
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Biological Information

  • Product Name
    Scoulerine
  • Note
    Research use only, not for human use.
  • Brief Description
    Scoulerine is an inhibitor of ?-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
  • Description
    Scoulerine is an inhibitor of ?-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.(In Vitro):Scoulerine shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively. Scoulerine shows antiplasmodial activity with IC50 values of 5.4 μM and 3.1 μM against the antifolate sensitive and the multidrug resistant P. falciparum strains: TM4/8.2 and K1CB1, respectively.
  • Synonyms
    (-)-Scoulerine; Discretamine
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6451-73-6
  • Formula Weight
    327.4
  • Molecular Formula
    C19H21NO4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1cc2CCN3Cc4c(C[C@H]3c2cc1O)ccc(OC)c4O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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