Scoulerine

Research use only, not for human use.

Scoulerine is an inhibitor of ?-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.

Scoulerine is an inhibitor of ?-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.(In Vitro):Scoulerine shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42, respectively. Scoulerine shows antiplasmodial activity with IC50 values of 5.4 μM and 3.1 μM against the antifolate sensitive and the multidrug resistant P. falciparum strains: TM4/8.2 and K1CB1, respectively.

(-)-Scoulerine; Discretamine

Apoptosis

Apoptosis

Apoptosis

——

——

6451-73-6

327.4

C19H21NO4

>98% (HPLC)

——

COc1cc2CCN3Cc4c(C[C@H]3c2cc1O)ccc(OC)c4O

——

(-20℃)

With Ice Pack

≥ 2 years