HBDDE

CAS No. 154675-18-0

HBDDE( —— )

Catalog No. M35086 CAS No. 154675-18-0

HBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than the PKCδ, PKCβI, and PKCβII isoenzymes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 451 Get Quote
5MG 692 Get Quote
10MG 943 Get Quote
25MG 1352 Get Quote
50MG 1822 Get Quote
100MG 2250 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    HBDDE
  • Note
    Research use only, not for human use.
  • Brief Description
    HBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than the PKCδ, PKCβI, and PKCβII isoenzymes.
  • Description
    HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis.
  • In Vitro
    HBDDE (50 μM; 5 hours) treatment reduces cell viability significantly by ~70%. HBDDE exhibits a marked increase in caspase-3 activity..Cell Viability Assay Cell Line:Cerebellar granule cells Concentration:50 μM Incubation Time:5 hours Result:Reduced cell viability significantly by ~70%.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis | PKC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    154675-18-0
  • Formula Weight
    338.31
  • Molecular Formula
    C16H18O8
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(OC)C1=C(C(O)=C(O)C(O)=C1)C2=C(COC)C=C(O)C(O)=C2O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60(6):809-15.?
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