
HBDDE
CAS No. 154675-18-0
HBDDE( —— )
Catalog No. M35086 CAS No. 154675-18-0
HBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than the PKCδ, PKCβI, and PKCβII isoenzymes.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 451 | Get Quote |
![]() ![]() |
5MG | 692 | Get Quote |
![]() ![]() |
10MG | 943 | Get Quote |
![]() ![]() |
25MG | 1352 | Get Quote |
![]() ![]() |
50MG | 1822 | Get Quote |
![]() ![]() |
100MG | 2250 | Get Quote |
![]() ![]() |
500MG | Get Quote | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NameHBDDE
-
NoteResearch use only, not for human use.
-
Brief DescriptionHBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than the PKCδ, PKCβI, and PKCβII isoenzymes.
-
DescriptionHBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis.
-
In VitroHBDDE (50 μM; 5 hours) treatment reduces cell viability significantly by ~70%. HBDDE exhibits a marked increase in caspase-3 activity..Cell Viability Assay Cell Line:Cerebellar granule cells Concentration:50 μM Incubation Time:5 hours Result:Reduced cell viability significantly by ~70%.
-
In Vivo——
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis | PKC
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number154675-18-0
-
Formula Weight338.31
-
Molecular FormulaC16H18O8
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(OC)C1=C(C(O)=C(O)C(O)=C1)C2=C(COC)C=C(O)C(O)=C2O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60(6):809-15.?
molnova catalog



related products
-
Nebularine
Nebularine (9-(beta-D-Ribofuranosyl)-9H-purine) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.
-
Trk-IN-9
Trk-IN-9 (Compound 12) is a potent inhibitor of TRK that inhibits the proliferation of Km-12 cell lines and induces apoptosis in a concentration-dependent manner.
-
LCH-7749944
LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis.?