SRTCX1003 ( SRTCX-1003 )

Catalog No. M10743 CAS No. 1203480-93-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

SRTCX1003
Note

Research use only, not for human use.
Brief Description

SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM.
Description

SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM, enhances deacetylation of cellular p65 protein with IC50 of 1.42 uM in cellular p65 acetylation assay; suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner, decreases the production of the proinflammatory cytokines TNFα and IL-12 in acute mouse model of LPS-induced inflammation.
Synonyms

SRTCX-1003
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

Sirtuin
Research Area

——
Indication

——

CAS Number

1203480-93-6
Formula Weight

449.53
Molecular Formula

C23H23N5O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

COC1=C(C=CC(=C1)C=CC(=O)C2=CC=C(C=C2)Cl)O.O
Chemical Name

2-(3-(2-morpholinoethoxy)phenyl)-N-(thiazol-2-yl)-1H-benzo[d]imidazole-7-carboxamide

1. Yang H, et al. PLoS One. 2012;7(9):e46364.
2. Kim SY, et al. PLoS One. 2015 Jul 15;10(7):e0133448.

Calculator

molnova catalog