UBCS039

Research use only, not for human use.

UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM.

UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM; shows robust activating effects on Sirt6-dependent H3K18ac deacetylation of full-length histone proteins and complete HeLa nucleosomes, with no statistically significant effects on basal Sirt1, 2, and 3 deacetylation activities; induces autophagosome accumulation and promotes autophagic flux in human cancer cells, triggers ROS accumulation and activates the AMPK/ULK1 signaling pathway.

UBCS-039;UBCS 039

Chromatin/Epigenetic

Sirtuin

Sirtuin

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358721-70-7

247.30

C16H13N3

>98% (HPLC)

DMSO : 125 mg/mL 505.48 mM

N12C(C(C3=CC=CN=C3)NC4=C2C=CC=C4)=CC=C1

4-(pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

(-20℃)

With Ice Pack

≥ 2 years