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UBCS039

CAS No. 358721-70-7

UBCS039 ( UBCS-039;UBCS 039 )

Catalog No. M14233 CAS No. 358721-70-7

UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    UBCS039
  • Note
    Research use only, not for human use.
  • Brief Description
    UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM.
  • Description
    UBCS039 (UBCS-039) is the first synthetic activator of the NAD+-dependent protein lysine deacetylase SIRT6 with EC50 of 38 uM; shows robust activating effects on Sirt6-dependent H3K18ac deacetylation of full-length histone proteins and complete HeLa nucleosomes, with no statistically significant effects on basal Sirt1, 2, and 3 deacetylation activities; induces autophagosome accumulation and promotes autophagic flux in human cancer cells, triggers ROS accumulation and activates the AMPK/ULK1 signaling pathway.
  • Synonyms
    UBCS-039;UBCS 039
  • Pathway
    Chromatin/Epigenetic
  • Target
    Sirtuin
  • Recptor
    Sirtuin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    358721-70-7
  • Formula Weight
    247.30
  • Molecular Formula
    C16H13N3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 125 mg/mL 505.48 mM
  • SMILES
    N12C(C(C3=CC=CN=C3)NC4=C2C=CC=C4)=CC=C1
  • Chemical Name
    4-(pyridin-3-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. You W, et al. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1007-1011.
2. Iachettini S, et al. Cell Death Dis. 2018 Sep 24;9(10):996.
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