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AK-7
CAS No. 420831-40-9
AK-7 ( AK 7;AK7 )
Catalog No. M14434 CAS No. 420831-40-9
A potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 15.5 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 38 | In Stock |
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| 5MG | 61 | In Stock |
|
| 10MG | 96 | In Stock |
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| 25MG | 177 | In Stock |
|
| 50MG | 312 | In Stock |
|
| 100MG | 512 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAK-7
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 15.5 uM.
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DescriptionA potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 15.5 uM; reduces cholesterol in cultured naive neuronal cells and brain slices from wild-type mice; shows neuroprotective activity in Huntington's disease mouse models, and reduces cholesterol in neuronal models.
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SynonymsAK 7;AK7
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PathwayChromatin/Epigenetic
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TargetSirtuin
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RecptorSirtuin
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number420831-40-9
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Formula Weight437.35
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Molecular FormulaC19H21BrN2O3S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=CC=CC(Br)=C1)C2=CC=CC(S(=O)(N3CCCCCC3)=O)=C2
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Chemical NameBenzamide, N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Taylor DM, et al. ACS Chem Biol. 2011 Jun 17;6(6):540-6.
2. Chopra V, et al. Cell Rep. 2012 Dec 27;2(6):1492-7.
3. Biella G, et al. J Alzheimers Dis. 2016 Jun 30;53(3):1193-207.
2. Chopra V, et al. Cell Rep. 2012 Dec 27;2(6):1492-7.
3. Biella G, et al. J Alzheimers Dis. 2016 Jun 30;53(3):1193-207.
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