Cart
sales@molnova.com
Home - Products - Autophagy - Autophagy - SP-8356

SP-8356

CAS No. 1454885-45-0

SP-8356( —— )

Catalog No. M26459 CAS No. 1454885-45-0

SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 237 Get Quote
10MG 375 Get Quote
25MG 709 Get Quote
50MG 963 Get Quote
100MG 1287 Get Quote
500MG 2601 Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SP-8356
  • Note
    Research use only, not for human use.
  • Brief Description
    SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.
  • Description
    SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.(In Vitro):In a time- and dose-dependent manner, SP-8356 (5-10?μM; 48 hours) inhibits the growth of various types of breast cancer cell lines. SP-8356 (10?μM; 48 hours) increases the percentage of MDA-MB231 cells in the S phase and decreases caspase-3 and cleaved PARP .(In Vivo):In a xenograft mouse model, SP-8356 (10?mg/kg; i.p.; every three days until the 42nd day) inhibits tumor growth . SP-8356 (50 mg/kg; p.o.; daily one day after carotid artery ligation for three weeks) prevents the formation of plaque and attenuates its vulnerability.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    COX-2| ROS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1454885-45-0
  • Formula Weight
    300.354
  • Molecular Formula
    C18H20O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [H][C@@]12C[C@@]([H])(C(\C=C\c3cc(O)c(O)c(OC)c3)=CC1=O)C2(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zhenggang Zhou, et al. PBN Protects NP Cells From AAPH-induced Degenerative Changes by Inhibiting the ERK1/2 Pathway. Connect Tissue Res. 2020 Mar 30;1-10.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Corynoxine hydrochlo...

    Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines including N2a and SHSY-5Y cells.

  • Mefloquine hydrochlo...

    A quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine; inhibits autophagy and has been recognized as a potential target for cancer therapy.

  • DMXAA

    A vascular disrupting agent (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 uM; activates STING dependent innate immune pathways.

Sign In Join Free